Isabelle had a tumor removed at another veterinary clinic 12/20/07. It was a poorly differentiated sarcoma that might have been fibrosarcoma, spindle cell, histiocytic sarcoma, or amelonotic melanoma. On 12/26/07, Isabelle was in pain from re-growth of the tumor. Neoplasene was applied to the tumor under general anesthetic and repeated on 12/29/07.